Understanding and Assessing Quantitative Modelling Research

This document provides an overview of how to critically assess a research article which uses quantitative, data-driven mathematical modelling to examine infectious disease transmission. Included is a Quick Reference Guide which aligns with the process of quantitative model development and the format of research articles and is meant to assist in a critical review of the research.

PHAC Wastewater Monitoring Program for COVID-19

Wastewater has already been used to show early detection of COVID-19 in some Canadian jurisdictions prior to an increase of clinically diagnosed cases. As COVID-19 can be characterized by symptomatic and asymptomatic infection, it is important to identify the presence of undiagnosed cases to minimize the likelihood of outbreaks.

Measles

Measles is a single stranded, enveloped RNA virus. The virus can cause a measles infection which starts in the respiratory epithelium of the nasopharynx. Measles is highly contagious. Complications from measles commonly include ear infections and diarrhea.

Group A Streptococcus

Group A streptococcus (GAS) is responsible for a range of diseases in humans. These diseases include strep throat (acute pharyngitis) and skin and soft tissue infections such impetigo and cellulitis. These can also include rare cases of invasive (serious) illnesses such as necrotizing fasciitis (flesh eating disease) and toxic shock syndrome (TSS).