NCCID Disease Debriefs provide Canadian public health practitioners, clinicians and advisors with up-to-date reviews of essential information on prominent infectious diseases for Canadian public health practice. While not a formal literature review, information is gathered from key sources including peer reviewed literature, the Public Health Agency of Canada (PHAC), the USA Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO).
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Questions addressed in this Debrief:
What is the current risk for Canadians from EVD?
Although it is quite possible that a person could arrive in Canada from an EVD affected country during the incubation period or after the onset of symptoms, the risk for Canadians is considered very low at this time. No case has ever been reported in Canada. The last WHO risk assessment, carried out on 5 August 2019, concluded that global risk levels remain low.
The Government of Canada provides relevant information to the Canadian public and travelers. Canada has protocols and resources to detect, investigate, and manage Ebola cases if it were ever to appear in the country. As of July 22, 2019 Ebola virus disease in DRC is at level 2 risk due to an outbreak that is only in limited geographic areas (see What is happening in the 2018-2019 outbreak?). While the Government of Canada recommends that Canadians avoid all non-essential travel to DRC due to current political instability and security risks, the WHO advises against travel restrictions to the DRC based on the current EVD outbreak. Canadian travelers to DRC are therefore advised to practice special health precautions.
- Government of Canada – Ebola virus disease: Health advice for travelers
- Government of Canada – Travel Health Notices
- WHO – Disease Outbreak News (August 8, 2019): EVD in DRC
What measures should be taken for a suspected EVD case or contact?
Health professionals in Canada are advised to be vigilant in the recognition, reporting, and prompt investigation of patients with a history of potential exposure to Ebola, and symptoms of EVD or similar diseases that can cause viral hemorrhagic fevers. Below you will find guidelines for public health management, infection prevention and control, clinical care, monitoring of travelers, testing, and reporting.
The Government of Canada and all provincial and territorial jurisdictions have case definitions for reporting purposes.
A specific EVD outbreak case definition was developed during the 2014-2016 West-Africa outbreak.
Public Health Management
The Government of Canada has developed guidance for public health management in the event that a human case of EVD or a close contact of an EVD case is identified. The WHO has developed other resources applicable to the Canadian context. Clinicians should also review applicable provincial/territorial guidance if they have been developed.
- Government of Canada – Public Health Management of Cases and Contacts of Ebola Virus Disease in the Community Setting in Canada
- WHO – Ebola Publications: Case Management
Patients under investigation for Ebola virus disease must be immediately reported as per national and jurisdictional protocols.
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under Reporting)
- Ebola Virus Disease Case Report Form
Surveillance and Monitoring
The Committee to Advise on Tropical Medicine and Travel (CATMAT) has developed interim recommendations for Canadians regarding preventive measures, and the monitoring and surveillance of travelers arriving from EVD affected areas.
- Government of Canada – Ebola Virus Disease Prevention, Monitoring and Surveillance Recommendations (written by CATMAT)
- WHO – Ebola Surveillance in countries with no reported cases of Ebola virus disease
Laboratory testing for a patient under investigation for Ebola virus disease must be done only with ongoing risk assessment and corresponding biosafety procedures. PHAC provides biosafety guidelines for laboratories handling specimens from patients under investigation for Ebola virus disease.
Ebola viral cultures can only be done at the National Microbiology Laboratory (NML) containment Level 4 laboratory. If a sample requires diagnostic testing for EVD, health professionals and laboratories should liaise with their provincial public health laboratory to coordinate with the NML.
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under Diagnosis)
- Government of Canada – Biosafety Guidelines for Laboratories Handling Specimens from Patients under Investigation for Ebola Virus Disease
Ebola clinical care guidelines for clinicians in Canada have been developed. Additionally, several guidance documents on clinical care and case management are available from the WHO.
- PHAC – Ebola Clinical Care Guidelines (written by the Canadian Critical Care Society, Canadian Association of Emergency Physicians, and the Association of Medical Microbiology & Infectious Diseases Canada)
- WHO – Ebola Publications: Case Management
Infection prevention and control (IPC) measures
The Government of Canada, the WHO, and the CDC have issued guidelines on IPC measures to be undertaken in a health care setting, including measures for environmental cleaning, and linen and waste management. The Government of Canada also provides guidelines on IPC measures for Pre-hospital care and ground transport of patients with suspected or confirmed EVD.
- Government of Canada-Infection prevention and control measures for pre-hospital care and ground transport of patients with suspected or confirmed Ebola virus disease
- Government of Canada – Infection Prevention and Control Expert Working Group: Advice on Infection Prevention and Control Measures for Ebola Virus Disease in Healthcare Settings
- Government of Canada-Advice on the Management of Ebola Virus Disease-associated Waste in Canadian Healthcare settings
IPC and environmental sanitation guidance has been developed for passenger conveyances and terminals, as well as airline cabin crews, cleaning, and cargo personnel. Some provincial/territorial jurisdictions have developed their own guidelines for IPC measures.
- Government of Canada – Environmental Sanitation Practices to Control the Spread of Communicable Disease in Passenger Conveyances and Terminals
- Government of Canada – Guidance for Airline Cabin Crews, Cleaning Personnel and Cargo Personnel: How to Protect Yourself and Others from Ebola Virus Disease
Other IPC Resources
- WHO – Ebola Publications: Infection Prevention and Control
- CDC – IPC for hospitalized patients under investigation for EVD in US hospitals
What is happening in the 2018-2019 EVD outbreak?
On 8 May 2018, an outbreak of Ebola virus disease (EVD) was announced by the Ministry of Health of the Democratic Republic of the Congo in Bikoro Health Zone, Equateur Province. As of 8 August 2019, a total of 2781 EVD cases were reported, including 2687 confirmed and 94 probable cases, of which 1866 cases died (overall case fatality ratio 67%). Of the total confirmed and probable cases, 56% (1572) were female, and 28% (791) were children aged less than 18 years. Three imported cases were reported in Uganda in June 2019, and there is a continued risk of spread to other neighbouring countries.
- WHO – Ebola Situation Reports of DRC Outbreak
- WHO-Statement on the first meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018
What else should I know about Ebola virus disease (EVD)?
Ebola Virus Disease (EVD) is caused by a virus within the genus Ebolavirus. Four strains of the virus (Ebola, Sudan, Taï Forest, and Bundibugyo) have been known to cause EVD in humans. The disease is rare and deadly, most commonly affecting people and nonhuman primates (monkeys, gorillas, and chimpanzees).
Signs, Symptoms and Severity
Typical symptoms include: sudden onset of fever, intense weakness, muscle pain, headache and sore throat, followed by vomiting, diarrhea, rash, impaired kidney and liver function, multiple organ failure, vascular manifestations (conjunctival injection, postural hypotension, edema), neurological signs (headache, confusion, coma) and in some cases, internal and external bleeding. Patients who present with these symptoms and signs should be isolated according to protocol, and then assessed to determine their risk of exposure to Ebola virus. Symptoms can begin 2 to 21 days after exposure, with an average of 8 to 10 days.
Case fatality of diagnosed cases has been 30–90%. The average case fatality rate is about 50%.
- Government of Canada – Symptoms and Treatment of Ebola virus disease
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under Causative Agents and Clinical Features)
- WHO – Ebola virus disease (under Symptoms)
EVD is generally limited geographically, occurring primarily in outbreak-prone areas of sub-Saharan Africa. Historically, between 1976 and 2012, sporadic cases and outbreaks of EVD were reported in several African countries. The largest recorded outbreak to date occurred from 2014-2016 in West Africa, with some imported cases appearing in other countries in Africa, Europe and North America. It resulted in over 28,500 cases and 11,300 deaths.
The ongoing 2018-2019 outbreak in the Democratic Republic of the Congo is highly complex and is the second largest Ebola outbreak on record (see: What is happening in the 2018-2019 EVD?”). Please read the statement from WHO declaring the Ebola outbreak in Congo a Public Health Emergency of International Concern .
To date, no cases of EVD have ever been identified in Canada. (See below: What is the current risk for Canadians from EVD outbreak?”).
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under History and context)
- Government of Canada – Ebola virus disease: Update on Outbreak in DRC
- WHO – Ebola virus disease (under introduction and Table: Chronology of previous EVD outbreaks)
- CDC-Ebola virus disease – History
The EVD resevoir is unconfirmed, but considered most likely to be fruit bats (Pteropodidae). Ebola is introduced into the human population through the close contact with the blood, organs, secretions, or other bodily fluids of infected animals such as chimpanzees, gorillas, fruit bats, monkeys, forest antelope and porcupines found ill or dead in the rainforest.
The virus spreads from person to person via broken skin or mucous membranes (eyes, nose or mouth) through direct, unprotected contact with:
- Blood or body fluids (urine, saliva, sweat, feces, vomit, breastmilk, and semen) of a person who is sick with or has died from Ebola Virus Disease (EVD)
- Objects (such as needles and syringes) contaminated with body fluids from a person sick with EVD or the body of a person who died from EVD
- Semen from a man who recovered from EVD (through oral, vaginal, or anal sex).
Transmission can also occur from animal-to-person through direct, unprotected contact with infected fruit bats or nonhuman primates (such as apes and monkeys).
The virus can remain in certain bodily fluids (including semen) of a patient who has recovered from EVD, even if they no longer have symptoms of severe illness. The risks of sexual transmission, however, are not well understood or confirmed. According to the World Health Organization, the most infectious body fluids are blood, feces, and vomit. Virus on surfaces may remain infectious from hours to days.
During an outbreak, those at higher risk of infection are:
- health workers
- family members or others in close contact with infected people
- people who have direct contact with bodies during funerary rituals/burials
2 to 21 days, usually between 4 to 10 days
Period of Communicability:
Patients become contagious once they begin to show symptoms; they are not thought to be contagious during the incubation period. The case remains communicable as long as the blood and body fluids (including seminal fluid and breastmilk) contain the virus. This includes the post-mortem period.
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under Transmission)
- CDC – Transmission
- WHO – Ebola virus disease (under Transmission)
Source: CDC, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Viral Special Pathogens Branch (VSPB)
Laboratory methods for confirming a case of EVD are based on isolation of the virus, detection of its RNA or components, and/or demonstration of antibodies against it. Ebola virus can be detected in the blood of an infected person three days after symptom onset by reverse-transcription polymerase chain reaction (RT-PCR)
The WHO describes (and has evaluated) several diagnostic methods used to confirm Ebola virus infection.
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under Diagnosis)
- WHO – Ebola virus disease (under Diagnosis)
Currently, there is no specific licensed treatment for Ebola. Patients are treated for their symptoms with supportive care. Some people are able to recover without treatment. The sooner the patient gets supportive care, the better their chances for recovery. Generally, treatment includes:
- Supportive blood pressure and oxygen delivery (reduce vomiting and diarrhea, fever and pain).
- Ensuring proper fluid and electrolytes levels (necessary minerals for the body), orally or intravenously.
- Strict isolation in an intensive care unit to prevent the disease from spreading to others.
- Government of Canada – EVD: For health professionals and humanitarian aid workers (under Treatment)
- WHO/The Lancet – Evidence-based guidelines for supportive care of patients with Ebola virus disease
A multi-drug randomized control trial began in November 2018 in DRC, and is now moving forward into an extension phase of the study with only two drugs, REGN-EB3 and mAb114. The two monoclonal antibody drugs, significantly outperformed the other two drugs tested (Zmapp and Remdesevir), and as of August 9, 2019, will be the only two drugs administered to patients.
In areas where Ebola is present, the current most important preventive strategies are: 1) implementation of infection prevention and control measures in health care settings; 2) public education with respect to reducing exposure to reservoir sources, ill people and their bodily fluids, and corpses in community settings; and 3) vaccination.
Individuals should continue to protect themselves from infection by not touching live or dead infected patients, or their body fluids such as blood, vomit, saliva, urine or feces. Even personal items can transmit the virus. Health workers should follow specific guidelines for infection control (See: What public health measures should be taken for a suspected EVD case or contact?)
- Government of Canada – Ebola virus disease: Prevention and Risks
- WHO – Ebola virus disease (scroll to Prevention and Control)
RVSV-ZEBOV, an investigational vaccine discovered by researchers at Canada’s National Microbiology Laboratory, is considered safe and protective against the Zaire strain of the Ebola virus. Immunization with the vaccine is recommended only in countries experiencing an Ebola outbreak, as the vaccine is not currently licensed. The rVSV-ZEBOV vaccine is being administered in the ongoing 2018-2019 Ebola outbreak in DRC.
- WHO – Ebola virus disease-frequently asked questions vaccine
- Government of Canada – Canada’s Ebola Vaccine Timeline
Other Relevant Ebola Links
- WHO Publications and Technical Guidance on Ebola
- WHO Ebola FAQ
- CDC Ebola Home Page
- CDC About Ebola Virus Disease-For Clinicians
- European Centre for Disease Prevention and Control (ECDC) Ebola page